Publikace detail

Interaction of the antitumor agent vanadocene dichloride with phosphate buffered saline

Autoři: Vinklárek Jaromír | Honzíček Jan | Holubová Jana

Rok: 2004

Druh publikace: článek v odborném periodiku

Název zdroje: Inorganica Chimica Acta

Název nakladatele: Elsevier Science SA

Místo vydání: Lausanne

Strana od-do: 3765-3769

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Interakce antitumorově aktivního vanadocendichloridu s fosfátovým pufrem	Interakce antitumorově aktivního vanadocendichloridu s fosfátovým pufrem	vanadocene dichloride; antitumor agents; EPR spectroscopy; DFT calculations; super-hyperfine coupling
eng	Interaction of the antitumor agent vanadocene dichloride with phosphate buffered saline	EPR study has shown that in aqueous solution the anticancer agent vanadocene dichloride (Cp2VCl2) interacts with phosphates contained in phosphate buffered saline (PBS). Chelate complex Cp2VO2PO2H (\A(iso)(V)\ = 189.0 MHz, \a(iso) (P)\ = 81.5 MHz and g(iso) = 1.9862) is only one paramagnetic compound formed at the range about the physiological pH (6.3-7.8). Its structure was validated by comparison of observed and theoretical calculated HFC tensor (at the density functional level of theory). (C) 2004 Elsevier B.V. All rights reserved.	vanadocene dichloride; antitumor agents; EPR spectroscopy; DFT calculations; super-hyperfine coupling

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