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HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY

Autoři: Pavlík Ivan | Vinklárek Jaromír

Rok: 1991

Druh publikace: článek v odborném periodiku

Název zdroje: EUROPEAN JOURNAL OF SOLID STATE AND INORGANIC CHEMISTRY

Název nakladatele: GAUTHIER-VILLARS

Místo vydání: PARIS, FRANCE

Strana od-do: 815-827

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY	By means of EPR spectroscopy various hydrolysis species formed from the vanadocene dichloride (I), Cp2VCl2 (Cp = eta-5-C5H5), in strongly acid, neutral and alkaline aqueous solutions were identified and characterized by the measured values of isotropic spectroscopic splitting factor g(iso) and isotropic hyperfine coupling constant A(iso). In strongly acid solutions the only vanadocene species [Cp2V(H2O)2]2+ (III; g(iso) = 1.9828, A(iso) = 7.92mT) is present (stable for several days). In strongly acid 0,103M NaCl solution the prevailing species III coexists in equilibrium with [Cp2V(H2O)Cl]+ (II; g(iso) = 1.9848, A(iso) = 7.68mT). The latter complex III was identified in concentrated HCl solutions, where it coexists in equilibria with either I or III depending on the HCl concentration. Vanadocene dihydroxide, Cp2V(OH)2, (V; g(iso) = 1.9907, A(iso) = 6.285mT) was the only vanadocene complex identified at physiological and higher pH values. Its EPR signal has completely disappeared after 72h-exposure of the solution on air.	EHRLICH ASCITES TUMOR; METALLOCENE DICHLORIDES; MECHANISTIC IMPLICATIONS; INHIBITION; INVITRO; V(ETA-5-C5H5)2CL2; TITANOCENE; CHEMISTRY; TITANIUM; CELLS
eng	HYDROLYSIS BEHAVIOR OF THE ANTITUMOR AGENT VANADOCENE DICHLORIDE IN STRONGLY ACID, NEUTRAL AND ALKALINE AQUEOUS-MEDIA - AN EPR STUDY	By means of EPR spectroscopy various hydrolysis species formed from the vanadocene dichloride (I), Cp2VCl2 (Cp = eta-5-C5H5), in strongly acid, neutral and alkaline aqueous solutions were identified and characterized by the measured values of isotropic spectroscopic splitting factor g(iso) and isotropic hyperfine coupling constant A(iso). In strongly acid solutions the only vanadocene species [Cp2V(H2O)2]2+ (III; g(iso) = 1.9828, A(iso) = 7.92mT) is present (stable for several days). In strongly acid 0,103M NaCl solution the prevailing species III coexists in equilibrium with [Cp2V(H2O)Cl]+ (II; g(iso) = 1.9848, A(iso) = 7.68mT). The latter complex III was identified in concentrated HCl solutions, where it coexists in equilibria with either I or III depending on the HCl concentration. Vanadocene dihydroxide, Cp2V(OH)2, (V; g(iso) = 1.9907, A(iso) = 6.285mT) was the only vanadocene complex identified at physiological and higher pH values. Its EPR signal has completely disappeared after 72h-exposure of the solution on air.	EHRLICH ASCITES TUMOR; METALLOCENE DICHLORIDES; MECHANISTIC IMPLICATIONS; INHIBITION; INVITRO; V(ETA-5-C5H5)2CL2; TITANOCENE; CHEMISTRY; TITANIUM; CELLS

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