Publikace detail

Oxidative stress and its impact on development of advanced coronary artery disease

Rok: 2007

Druh publikace: článek ve sborníku

Název zdroje: Clinical Chemistry and Laboratory Medicine Special Supplement

Název nakladatele: Walter de Gruyter GmbH & Co. KG

Místo vydání: Berlin

Strana od-do: S241

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Oxidační stres a jeho význam pro rozvoj onemocnění koronárních tepen	Oxidační stres a jeho význam pro rozvoj onemocnění koronárních tepen	oxidační stres; onemocnění koronárních tepen
eng	Oxidative stress and its impact on development of advanced coronary artery disease	Background. The disbalance of redox equilibrium plays a role in development of atherosclerosis. The aim of this study was to asses the impact of oxidative stress and antioxidative status in patients with advanced coronary artery disease. Methods. Oxidative stress parameters were determined in group of patients with serious coronary artery disease (at least 50% stenosis of the left main coronary artery or 70% stenosis of other coronary artery according to coronarographic examination; S,n=40) and control group with normal coronary artery status (C,n=38). Free radical concentration was determined by spectrophotometric assay based on chlorophyllin acceptance of electrons, total antioxidant capacity using kit TAS (Randox, UK), malondialdehyde, glutathione and a-tocopherol plasma concentration by HPLC. Plasma levels of allantoin, a-1antiproteinase, total cholesterol, triglycerides, HDL-ch, LDL-ch, fibrinogen and hsCRP were followed. Results. In patients with coronary stenosis (S) higher level of free radicals (FR) coincided with lower level of lipid standardised a-tocopherol (AT). FR: S: 5.11+-0.58mmol/l vs C: 4.60+-0.79mmol/l (p<0.01); AT: S: 2.78+-0.45umol/l vs C: 3.00+-0.39umol/l (p<0.05). In S group significantly (p<0.05) higher levels of GSSG/GSH ratio (S: 8.09+-3.86% vs C: 6.13+-2.21%), a-1antiproteinase, allantoin, triglycerides and fibrinogen were found. Conclusion. According to correlation analysis, the increased level of free radicals in patients with coronary atherosclerosis was intimately related to the presence of hypertriglyceridemia and lower levels of lipid-standardised a-tocopherol, thereby suggesting that abnormalities in both lipid metabolism and antioxidative substance levels underlie the increased oxidative stress in advanced atherosclerosis.	oxidative stress; coronary artery disease

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