Publikace detail

Henryho reakce: Nové měďnaté komplexy na bázi mono- a bis(imidazolyl)pyridinů

Autoři: Keder Roman | Drabina Pavel | Hanusek Jiří | Sedlák Miloš

Rok: 2005

Druh publikace: článek ve sborníku

Název zdroje: ChemZi

Název nakladatele: Slovenská chemická spoločnosť

Místo vydání: Bratislava (Slovenská republika)

Strana od-do: 214-215

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Henryho reakce: Nové měďnaté komplexy na bázi mono- a bis(imidazolyl)pyridinů	In recent years, it intensively increases development of synthesis and characterisation of new chiral ligands and their transition metal complexes. These complexes are especially used as a homogeneous catalysts in asymmetric synthesis. We have prepared new ligands based on mono- and bis(imidazolonyl)pyridines, from optically pure 2-amino-2,3-dimethylbutanamides and ethyloxycarbonyl pyridine 2-carboxylic acid or pyridine-2,6-dicarboxylic acid dichloride, followed by subsequent ring closure reaction giving imidazolone cylce. The last step was N-alkylation of imidazolones by different alkylation agents. Ligands prepared in this way were characterised using 1H and 13C NMR spectroscopy. Finally were prepared complexes of ligands with cobalt(II) and copper(II) acetate. These metal complexes were used as enantioselective catalysts for Henry?s reaction. The monoimidazolonylpyridines ligands gives nitroaldol products with yield 49 ? 93% and maximal optical yield 15,6%, however bis(imidazolonyl)pyridines gives only racemic products.	Imidazolonpyridiny, Mědnaté komplexy, Henryho reakce
eng	Henry΄s reaction: New copper(II) complexes based on mono- and bis(imidazolyl)pyridines	In recent years, it intensively increases development of synthesis and characterisation of new chiral ligands and their transition metal complexes. These complexes are especially used as a homogeneous catalysts in asymmetric synthesis. We have prepared new ligands based on mono- and bis(imidazolonyl)pyridines, from optically pure 2-amino-2,3-dimethylbutanamides and ethyloxycarbonyl pyridine 2-carboxylic acid or pyridine-2,6-dicarboxylic acid dichloride, followed by subsequent ring closure reaction giving imidazolone cylce. The last step was N-alkylation of imidazolones by different alkylation agents. Ligands prepared in this way were characterised using 1H and 13C NMR spectroscopy. Finally were prepared complexes of ligands with cobalt(II) and copper(II) acetate. These metal complexes were used as enantioselective catalysts for Henry?s reaction. The monoimidazolonylpyridines ligands gives nitroaldol products with yield 49 ? 93% and maximal optical yield 15,6%, however bis(imidazolonyl)pyridines gives only racemic products.	Imidazolonepyridines, Copper(II) complexes, Henry΄s reaction

Search

Přihlášení pro studenty

Přihlášení pro zaměstnance

Publikace detail

Katedry

Ústavy a pracoviště

Jak nás najdete?

Služby

Často hledáte