Publikace detail

Structure of azo dye organotin(IV) compounds containing a C,N-chelating ligand, part II, and their in vitro antifungal activity

Rok: 2005

Druh publikace: článek v odborném periodiku

Název zdroje: Applied Organometallic Chemistry

Název nakladatele: John Wiley & Sons Ltd.

Místo vydání: Chichester

Strana od-do: 500-509

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Structure of azo dye organotin(IV) compounds containing a C,N-chelating ligand, part II, and their in vitro antifungal activity	Eight complexes of azo dyes used in routine industrial processes and the [(2-dimethylaminomethyl) phenyl](R-2)tin(IV) moiety (R = Ph or n-Bu) have been prepared, their NMR, electrospray ionization mass spectrometry, IR and UV-VIS spectra measured, and the X-ray structure of ([2-(N,N-dimethylaminomethyl)phenyl](diphenyl))tin(IV)-2-{[N'-(2-oxo-1-phenylcarbamoylpropyliden)hydrazo]}benzoate (3a), determined. The compounds reveal similar structures in chloroform solution (NMR) and in the solid state (X-ray, IR). Four compounds exist in the hydrazone tautomeric form. The central tin atoms in all compounds exist in slightly distorted trans-trigonal bipyramidal geometry with the 'negative' atoms (nitrogen, oxygen) in axial and the carbon atoms in equatorial positions; no intramolecular attacks from the dyes' cores were observed. The in vitro antifungal activity of the compounds studied was comparable to similar organotin(IV) compounds and antifungal drugs in clinical use. Copyright (c) 2005 John Wiley E Sons, Ltd.
eng	Structure of azo dye organotin(IV) compounds containing a C,N-chelating ligand, part II, and their in vitro antifungal activity	Eight complexes of azo dyes used in routine industrial processes and the [(2-dimethylaminomethyl) phenyl](R-2)tin(IV) moiety (R = Ph or n-Bu) have been prepared, their NMR, electrospray ionization mass spectrometry, IR and UV-VIS spectra measured, and the X-ray structure of ([2-(N,N-dimethylaminomethyl)phenyl](diphenyl))tin(IV)-2-{[N'-(2-oxo-1-phenylcarbamoylpropyliden)hydrazo]}benzoate (3a), determined. The compounds reveal similar structures in chloroform solution (NMR) and in the solid state (X-ray, IR). Four compounds exist in the hydrazone tautomeric form. The central tin atoms in all compounds exist in slightly distorted trans-trigonal bipyramidal geometry with the 'negative' atoms (nitrogen, oxygen) in axial and the carbon atoms in equatorial positions; no intramolecular attacks from the dyes' cores were observed. The in vitro antifungal activity of the compounds studied was comparable to similar organotin(IV) compounds and antifungal drugs in clinical use. Copyright (c) 2005 John Wiley E Sons, Ltd.	organotin(IV) compounds; azo dyes; C,N-chelating ligand; NMR; X-ray diffraction; electrospray ionization mass spectrometry; azo-hydrazone tautomerism

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