Publikace detail

Die nichtalkoholische Fettlebererkrankung (NAFLD) ist mit einer qualitativen Änderung der HDL-Lipoproteine und deren Fetsäurenmuster assoziiert

Autoři: Kantartzis Konstantinos | Rittig Kilian | Čegan Alexander

Rok: 2007

Druh publikace: článek ve sborníku

Název zdroje: Diabetologia

Název nakladatele: Springer

Strana od-do: S47-S48

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Nealkoholická steatóza jater (NESJA) je spojena s kvantitativní změnou HDL-lipoproteinů a obsahem jejich mastných kyselin	Nealkoholická steatóza jater (NESJA) je spojena s kvantitativní změnou HDL-lipoproteinů a obsahem jejich mastných kyselin	Játra; steatóza; tuk; HDL-C; závislost; mastné kyseliny
eng	Nonalcoholic fatty liver disease (NAFLD) is associated with a qualitative change in the HDL-C lipoprotein sub-fractions and their fatty acids patterns	Fatty liver is associated with insulin resistance, atherosclerosis and the metabolic syndrome and predicts future cardiovascular events. The pro-atherogenic serum lipid profile in subjects with fally liver is characterized by elevated levels of triglycerides, low high-density lipoprotein cholesterol (HDL-C) and an increase in small, dense low-density lipoprotein (LDL) particles. For HDL-C not only quantitative, but also qualitative and compositional alterations are related to its anti-atherogencic properties. Particularly circulating HDL2-cholesterol (HDL2-C) was found to protect from atherosclerosis. In the present study we investigated first, whether fatty liver is associated with altered circulating HDL-C sub-fractions and second whether this relationship is independent of visceral adiposity and insulin sensitivity, thus possibly representing a direct link between fatty liver and cardiovascular disease.	Liver; steatosis; fatt; HDL-C; dependence; fatty acids

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