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Synthesis of substituted S-(1-benzofuran-2(3H)-on-3-yl) isothiuronium bromides and their rearrangement to 5-(2-hydroxyphenyl)-2-imino-1,3-thiazolidin-4-ones

Autoři: Hanusek Jiří | Kammel Richard

Rok: 2012

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

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Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthesis of substituted S-(1-benzofuran-2(3H)-on-3-yl) isothiuronium bromides and their rearrangement to 5-(2-hydroxyphenyl)-2-imino-1,3-thiazolidin-4-ones	In this work we focused on synthesis of substituted S-(1-benzofuran-2(3H)-on-3-yl) isothiuronium bromides and their rearrangement to 5-(2-hydroxyphenyl)-2-imino-1,3-thiazolidin-4-ones. This rearrangement is subject to acid-base catalysis and proceed under very mild conditions, even at physiological pH which has great importance, not only for the synthesis of 1,3-thiazolidin-4-ones, but also for their potential application as pro-drugs. Therefore we studied kinetics and detailed reaction mechanism of the rearrangement using UV-VIS spectroscopy in aqueous buffer solutions.	Synthesis; S-(1-benzofuran-2(3H)-on-3-yl)isothiuronium-bromides; rearrangement; 5-2-hydroxyphenyl-2-imino-1,3-thiazolidin-4-ones

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