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The plasma phospholipid and triglyceride fatty acid profile in type 2 diabetes mellitus patients
Autoři: Čermák Tomáš | Mužáková Vladimíra | Laštovička Petr | Štramová Xenie | Čegan Alexander
Rok: 2012
Druh publikace: ostatní - přednáška nebo poster
Strana od-do: nestránkováno
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Jazyk Název Abstrakt Klíčová slova
eng The plasma phospholipid and triglyceride fatty acid profile in type 2 diabetes mellitus patients Diabetes mellitus is a widespread metabolic disease, which involves numerous metabolic disorders including dyslipidemia. The aim of our pilot study was to compare fatty acid profile of diabetic and healthy subjects. The fatty acid composition of fasting plasma phospholipids and triglycerides has been analysed in patients diagnosed with type 2 diabetes mellitus (NIDDM), aged 31-84 years (n=23) and in control group of healthy voluntary blood donors (n=10). Different fatty acid composition was found mainly in the PL fraction. NIDDM plasma phospholipids contained lower concentrations of ω-3 fatty acids, mainly of octadecatetraenoic - 18:4 ω3 (P = 0.043), eicosapentaenoic - 20:5 ω3 (P = 0.00055) and docosahexaenoic acid - 22:6 ω3 (P = 0.00009). Only α-linolenic acid - 18:3 ω3 was significantly higher in comparison with the control group. The concentration of ω-6 fatty acids (P = 0,008) [eicosatrienoic - 20:3 ω6 (P = 0.000002) and arachidonic acid - 20:4 ω6 (P = 0.000063)] was significantly lower in NIDDM patients. The NIDDM group exhibited significantly lower content of saturated fatty acids (P=0.00015), which was given mainly by lower abundance of stearic acid 18:0 (P ≤ 0.0001). The myristic acid - 14:0 (P = 0.004) was higher and behenic acid - 22:0 (P ≤ 0.0001) was lower, while MUFAs – palmitoleic - 16:1 ω7 (P ≤ 0.0001), oleic - 18:1 ω9 (P ≤ 0.00001) and octadecanoic acids - 18:1 ω7 (P ≤ 0.00001) were significantly higher in NIDDM group. The breach of the plasma fatty acid compositions is an important pathogenetic part of the metabolic syndrom and NIDDM development. diabetes mellitus; fatty acid composition; MUFA; PUFA; Δ-6 desaturase

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