Univerzita PardubiceFakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Novel inhibitors of cholinesterases for treatment of Alzheimer disease

Autoři: Vorčáková Katarína | Štěpánková Šárka | Vytřas Karel

Rok: 2014

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Novel inhibitors of cholinesterases for treatment of Alzheimer disease	The cholinesterases (ChEs) are key enzymes in a range of important areas such as neurobiology, toxicology and pharmacology. Of these, two major groups, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), play important roles in human and animal function. Alzheimer´s disease (AD) is an age dependent neurodegenerative disorder that destroys brain cells. There are many hypotheses of the etiology of this disease. The cholinergic hypothesis relates with increased activity of AChE and the neurodegeneration with the loss of cholinergic neurotransmission. AChE is an enzyme primarily responsible for the rapid elimination of acetylcholine (ACh), within one millisecond after its release at cholinergic synapses. Nowadays, for treatment of AD inhibitors of ChEs are used.	Novel inhibitors; cholinesterases; Alzheimer disease