Publikace detail

Omega-3 fatty acid supplementation candidates can be selected using fatty acid profiling

Rok: 2015

Druh publikace: článek v odborném periodiku

Název zdroje: European Journal of Lipid Science and Technology

Název nakladatele: Wiley-VCH

Místo vydání: Weinheim

Strana od-do: 601-607

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Přidavky do potravin omega -3 mohou být vybrány na základě mastných kyselin	Cílem práce bylo zhodnocení profilu mastných kyselin v plazmě a erytrocytech u zdravých mužů s rýznými kardiovaskulárními onemocněními. Mastné kyseliny v plazmě byly analyzovány v pěti skupinách pacientů ve věku 37-57 let. Profil mastných kyselin byl měřen pomocí plynové chromatografie s plamenově ionizační detekcí.
eng	Omega-3 fatty acid supplementation candidates can be selected using fatty acid profiling	The aim of this study was to evaluate the fatty acid(FA) profile in the plasma and erythrocyte membranes of apparently healthy men compared to male patients with various cardiovascular diseases (CVD). The plasma FA profiles were analyzed in five groups of subjects aged 37-57 years: groups 1 and 2 were male voluntary blood donors with a body mass index(BMI) 25.1 +/- 1.6,(Group1, N = 12) and a BMI 32.9 +/- 4.5, (Group 2, N = 11) respectively, male patients with chronic heart failure due to dilated cardiomyopathy (Group 3, N = 10), chronic atrial fibrillation without heart failure or coronary heart disease (Group 4, N = 10) and patients after myocardial infarction (Group 5, N = 11). The FA profile in plasma and erythrocytes was measured by gas chromatography (GC) with flame ionization detection and basic plasma lipid parameters were then estimated. Deficiencies of eicosapentaenoic acid and docosahexaenoic acid were found in all the groups of CVD patients and in Group 2 (BMI 32.9 +/- 4.5) of this Central European population. Unfavorable alterations in FA composition and clinical biochemistry parameters were found in patients with dilated cardiomyopathy (Group 3). Further, 75% of Group 1 (blood donors) had an average plasma PUFA level in the worst quartile for relative risk of cardiovascular events. Tailored n-3 PUFA supplementation should be recommended not only for secondary prevention in patients suffering from CVD but also for primary prevention in overweight and obese persons with a proven deficiency.	Cardiovascular diseases; Lipidomics; n-3 PUFA; n-6 PUFA; Obesity

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