Publikace detail

Series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes as new catalysts for Henry reaction

Autoři: Horáková Eva | Nováková Gabriela | Drabina Pavel | Sedlák Miloš

Rok: 2016

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one Cu-complexes as new catalysts for Henry reaction	The aim of this work was preparation of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-one derivatives 1-3 and their corresponding Cu(II) complexes. These compounds were studied as enantioselective catalysts for the asymmetric Henry reaction of various aldehydes with nitromethane. It was found the 5-tert-butyl derivatives are effective catalysts for this reaction, with enantiomeric excesses being as high as 97%. The enantioselectivities of individual derivates 1-3 are different and depend on the alkyl substituents attached to stereogenic centres and the configuration of imidazolidine-4-one cycle. The most efficient derivative was found to be the Cu(II)-complex of derivative 1. Its enantiocatalytic activity is comparable with the best so far known enantioselective catalysts of the Henry reaction.

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