Publikace detail

Novel potential proteasomal inhibitors based on salicylamides - synthesis, biological activities and cytotoxicity

Autoři: Dušek Jan | Imramovský Aleš | Pauk Karel | Jorda R | Kryštof V

Rok: 2016

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Novel potential proteasomal inhibitors based on salicylamides - synthesis, biological activities and cytotoxicity	Presented work is aimed to prepare new compounds (O‑benzyl-5-chlorosalicyl-tripeptide aldehydes, O-benzyl-5-chlorosalicyl-dipeptide aldehydes and other derivatives) which should join a large group of proteasome inhibitors. Proteasomal inhibition via blocking its protein recycling function is one of a very promising ways to treat tumor cells or multiple myeloma. The novel potential inhibitors based on the salicylic acid and di- and tripeptide scaffold were designed and synthesized.	Salicylamides; Proteasomal inhibitors; Biological activity; Cytotoxicity

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