Publikace detail

New Synthetic Approach to Selected Parts of Prostaglandin Analogues.

Autoři: Monteiro Sara | Pauk Karel | Imramovský Aleš

Rok: 2016

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	New Synthetic Approach to Selected Parts of Prostaglandin Analogues.	Current efforts are being targeted for the development of a new approach to synthesize the propargyl alcohol connection which is present in alfaprostol molecule. The synthesis should be performed using as starting materials a Corey lactone derivative and 3-cyclohexylpropanal. The stereochemistry of the hydroxyl group should be taken into account during the procedure, once just the (S)-enantiomer is active. The presence of the (R)-enantiomer requires extra purification steps which represents lost of time and resources.	Prostaglandin; Corey lactone; 3-cyclohexylpropanal

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