Publikace detail

Application of Asymmetric Henry Reaction in the Preparation of Clavaminol A and Xestoaminol C

Autoři: Nováková Gabriela | Drabina Pavel | Sedlák Miloš

Rok: 2018

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

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Jazyk	Název	Abstrakt	Klíčová slova
eng	Application of Asymmetric Henry Reaction in the Preparation of Clavaminol A and Xestoaminol C	Sphingolipids are ubiquitous components of eukaryotic cell membranes. They are found in essentially all animals, plants, and fungi, as well as some bacteria and viruses. They are composed of sphingoid bases, amide-linked fatty acids and headgroups. [1] Over the past decade, sphingoid bases have achieved considerable attention due to their significant biological activity. Sphingosine and its derivatives such as Spisulosine, Clavaminols, Xestoaminols etc. have been screened for their anticancer activity. [2,3] These derivatives can be prepared by a variety type of syntheses [2-5] including nitroaldol reaction and subsequent reduction of nitro group (Figure 1.). The aim of this work was the study of catalytic activity and enantioselectivity of prepared Cu(II) complexes of substituted 2-(pyridine-2-yl)imidazolidine-4-thione [6] in the preparation of biological active compounds Clavaminol A and Xestoaminol C. The catalytic activity of these prepared catalysts was compared with other efficient catalysts for asymmetric Henry reaction. It was found out, that the most efficient catalyst provided corresponding nitroalcohols with enantioselectivity more than 90 % ee. Nowadays, the catalytic activity and recyclability of immobilized forms of catalysts are studied.	Asymmetric Henry Reaction; Clavaminol A; Xestoaminol C; Cu(II) complexes; 2-(pyridine-2-yl)imidazolidine-4-thione

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