Publikace detail

Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications

Rok: 2018

Druh publikace: článek v odborném periodiku

Název zdroje: Journal of materials science - materials in medicine

Název nakladatele: Springer

Místo vydání: Heidelberg

Strana od-do: "32-1"-"32-8"

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Usměrněné nanovlákna poly(3-hydroxybutyrate) graftovaného na hyaluronan pro potenciální léčebné aplikace	Hybridní komposit poly(3-hydroxybutyrát) graftovaný na hyaluronan (HA) byl syntetizován a charakterizován. Takto připravený materiál byl zvlákněn pomocí elektrospinningu a byla sledována závislost Mw na průměru vláken.	skafold; růst buněk; polyhydroxyalkanáty
eng	Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications	In this work, a hybrid copolymer consisting of poly(3-hydroxybutyrate) grafted to hyaluronic acid (HA) was synthesised and characterised. Once formed, the P(3HB)-g-HA copolymer was soluble in water allowing a green electrospinning process. The diameters of nanofibres can be tailored by simply varying the M-w of polymer. The optimization of the process allowed to produce fibres of average diameter in the range of 100-150 nm and low polydispersity. The hydrophobic modification has not only increased the fibre diameter, but also the obtained layers were homogenous. At the nanoscale, the hybrid copolymer exhibited an unusual hairy topography. Moreover, the hardness and tensile properties of the hybrid were found to be superior compared to fibres made of unmodified HA. Particularly, this reinforcement was achieved at the longitudinal direction. Additionally, this work reports the use in the composition of a water-soluble copolymer containing photo cross-linkable moieties to produce insoluble materials post-electrospinning. The derivatives as well as their nanofibrous mats retain the biocompatibility of the natural polymers used for the fabrication.	scaffolds; growth; acid; polyhydroxyalkanoates

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