Publikace detail

Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals-The Case of Simvastatin

Rok: 2020

Druh publikace: článek v odborném periodiku

Název zdroje: Pharmaceutics

Název nakladatele: MDPI

Místo vydání: BASEL

Strana od-do: "384-1"-"384-21"

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
cze	Důležitost velikosti částic mezoporézní siliky pro stabilizaci amorfních léčiv - Případ Simvastatin	Práce studuje roli mezoporézní siliky pro stabilizaci amorfního léčiva Simvastatin. Inhibice rekrystalizace je sledována metodami DSC a BDS.	simvastatin; amorfní léčiva; mezoporézní silika; stabilizace; rekrystalizace
eng	Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals-The Case of Simvastatin	In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid((R)) XDP 3050 and Syloid((R)) 244 FP) were employed. The crystallization tendency of SVT alone and in mixture with the MS materials was investigated by Differential Scanning Calorimetry (DSC) and Broadband Dielectric Spectroscopy (BDS). Neither confinement of the SVT molecules inside the MS pores nor molecular interactions between functional groups of the SVT molecules and the surface of the stabilizing excipient could explain the observed stabilization effect. The stabilization effect might be correlated with diffusion length of the SVT molecules in the MS materials that depended on the particle size. Moreover, MS materials possessing different particle sizes could offer free spaces with different sizes, which might influence crystal growth of SVT. All of these factors must be considered when mesoporous materials are used for stabilizing pharmaceutical glasses.	simvastatin; amorphous pharmaceuticals; mesoporous silica; stabilization; recrystallization

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