Univerzita Pardubice Fakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Synthetic pathways towards fused pyrazine derivatives

Autoři: Prokopová Eva | Bureš Filip | Burešová Zuzana | Klikar Milan

Rok: 2023

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthetic pathways towards fused pyrazine derivatives	Pyrazine derivatives are well-known six membered aromatic heterocyclic compounds bearing two nitrogen atoms. To this day, several methods enabling synthesis of pyrazine are known. The most popular method utilized in construction of pyrazine ring involves condensation of 1,2-diamines with 1,2-dicarbonyl compounds (benzils). Hence, as a part of our ongoing research activity, we have explored a condensation reaction of 1,2-diamines (especially diaminomaleonitrile) with planar 1,2-diketones such as for example phenantrene-9,10-quinone or benzo[1,2-b;4,3-b´]dithiophene-4,5-quinonone). Variety of solvents, catalysts, bases and acids were screened in these condensations to probe their feasibility. Moreover, a reversed synthetic strategy was also attempted, which allowed to compare reactivity of electron-rich thiophene and benzene amines/ketones.	pyrazine; 1,2-diamines; 1,2-diketones; condensation