Univerzita Pardubice Fakulta chemicko- technologická

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Publikace detail

Switchable Directed C–H Activation Reactions

Autoři: Korábková Tereza | Konopáčová Pavlína | Kocúrik Martin | Váňa Jiří

Rok: 2023

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Switchable Directed C–H Activation Reactions	Directing group (DG) assisted C–H activation is a key step of the intensively studied C–H functionalization reactions. One of the benefits of this approach is possibility of decoration of the basic skeleton of the molecule in the last stages of the synthesis – the so called Late Stage Functionalisations (LSF). An interesting option is the use of either one directing group for the targeted activation of various C–H bonds, or the control and easy switching of regioselectivity for substrates containing multiple directing groups. The first approach usually involves the choice of different catalytic systems. The solution proposed by us assumes the introduction of the original concept of photoswitchable directing groups. The functionality of the principle is illustrated on suitably chosen aromatic azobenzenes, where, depending on the configuration of the photoisomerizable azo group, activation of various C–H bonds occurs. The second approach targeted to substrates containing multiple DG takes advantage of the fact that the stronger DG tends to be more basic. Therefore, the addition of an acid to the reaction mixture causes its protonation and thus the loss of DG ability, which allows the weaker DG to direct the reaction.	C–H activation; photoswitchable groups; azobenzenes