Univerzita PardubiceFakulta chemicko- technologická

Univerzita Pardubice

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Publikace detail

Polymer-Supported Pd Catalysts with Amino Acid–Derived Ligands: Mechanistic Investigation

Autoři: Bartáček Jan | Kocúrik Martin | Pochobradský Jaroslav | Hlavatý Tomáš | Sedlák Miloš

Rok: 2025

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Polymer-Supported Pd Catalysts with Amino Acid–Derived Ligands: Mechanistic Investigation	Developing recyclable catalytic systems and gaining mechanistic insight into the long-term efficiency of Pd(II) complexes in key transformations motivates this study, which examines polymer-immobilized Pd(II) catalysts with two classes of amino acid–derived ligands (Fig. 1). Pyridine–oxazoline (PyOx) ligands are employed for the asymmetric addition of arylboronic acids to enones1, nitrostyrenes2, and cyclic N-sulfonyl ketimines3. Mono-protected amino acid (MPAA) ligands are used in Pd-catalyzed dual C–H functionalization of indole derivatives. Catalysts were prepared by copolymerization or post-functionalization on polystyrene PEG supports. Mechanistic characterization, combining spectroscopic and analytical methods, allows direct observation of phenomena such as the reduction of Pd(II) to Pd(0), formation of palladium nanoparticles, and the effects of solvent and substrate structure on catalyst stability and performance. Comparative analysis of different systems reveals how polymer immobilization not only facilitates catalyst recovery but also exposes otherwise hidden limitations in metal speciation and catalyst lifetime, providing a more nuanced understanding of the factors governing the efficiency and robustness of these transformations.	Polymer-immobilized Pd(II); Amino acid (MPAA) ligands; C–H functionalization; Indole derivatives