Univerzita PardubiceFakulta chemicko- technologická

Univerzita Pardubice

Zaměstnanci
|
Studenti
English

Publikace detail

Testing the disinfectant effects of biodegradable oligomeric compounds

Autoři: Baslerová Nikola | Pejchalová Marcela | Olejník Roman

Rok: 2025

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Testing the disinfectant effects of biodegradable oligomeric compounds	Introduction. During the COVID-19 pandemic, the demand for disinfectants increased. However, their overuse and misuse also increased. This can lead to a worsening of the problem of antimicrobial resistance, but also to serious impacts on ecosystems and human health. An ideal disinfectant should be effective even at low concentrations, gentle on human health, and effective against a wide range of microorganisms. It should also be easily biodegradable, environmentally friendly, and cheap to produce, which could be achieved by lactic acid biopolymers. Nowadays, biopolymers are crucial mainly due to their origin from renewable sources and non-toxic nature. In a regular laboratory, the bacterial effectiveness of a disinfectant can be demonstrated using the method described in the ČSN EN 13727+A2 standard. Methodology. The first step was to determine the minimum inhibitory concentration (MIC) using the dilution method in 24- well plates. The MIC was determined for four microorganisms – Escherichia coli (CCM 4517), Staphylococcus aureus (CCM 4516), Pseudomonas aeruginosa (CCM 7930), Enterococcus hirae (CCM 4533). Thirteen substituted lactyl-lactates synthesized at the Department of General and Inorganic Chemistry, University of Pardubice were tested in this way. Only one of them was further tested according to the ČSN EN 13727+A2 standard. Results. The most promising sample was tested in this work according to the ČSN EN 13727+A2 standard in 1.5% and 2% concentration. The 2% concentration of the tested substance was not effective on Enterococcus hirae. At the same time, the sample was sent to the accredited laboratory EMPLA. There, according to the ČSN EN 13727+A2 standard, the tested substance met the requirements for reduction in 3% concentration. Conclusion. The tested sample shows a bactericidal effect even at a low concentration (3%) compared to, for example, alcohol (30%) or povidone-iodine, which is typically produced in a concentration of 7.5-10%	desinfectants; oligomeric oligomeric coumpounds; PLA,