Univerzita Pardubice Fakulta chemicko- technologická

Univerzita Pardubice

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English

Publikace detail

Synthesis and Biological Studies of (±)Trans-N-(2-Phenylcyclopropyl)Carbamates as Cholinesterase Inhibitors

Autoři: Horáková Eva | Drabina Pavel | Štěpánková Šárka | Královec Karel | Sedlák Miloš

Rok: 2016

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthesis and Biological Studies of (±)Trans-N-(2-Phenylcyclopropyl)Carbamates as Cholinesterase Inhibitors	The aim of this work was the preparation and characterization of serie of N-(2-phenylcyclopropyl)carbamate derivatives. These compounds were tested as potential inhibitory agent for AChE and BChE by Ellman method. It was found out, that all of these carbamates are better inhibitors of AChE and BChE than commercial Rivastigmin. Furthemore, the carbamates were tested for cytotoxicity and partition coefficients Pow were determined.