Publikace detail

Synthesis of substituted chiral 6-fluorobenzothiazole 4-aminobenzodiamides as potential antifungal agents

Autoři: Pejchal Vladimír | Pejchalová Marcela | Svobodová Barbora

Rok: 2018

Druh publikace: ostatní - přednáška nebo poster

Strana od-do: nestránkováno

Tituly:

Jazyk	Název	Abstrakt	Klíčová slova
eng	Synthesis of substituted chiral 6-fluorobenzothiazole 4-aminobenzodiamides as potential antifungal agents	The starting compound (R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethanamine was prepared as the corresponding p-toluenesulfonate salt. A series of novel 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted 4-aminobenzodiamides were synthesized by simple and technologically applicable three-steps reaction. Their structures were confirmed by 1H, 13C and 19F NMR spectra, high resolution mass spectrometry and elemental analyses. The optical activities were confirmed by optical rotation measurements.	1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted 4-aminobenzodiamides; optical activity; NMR

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